Medical Dictionary


noun apro·ti·nin \ā-ˈprōt-ə-nin\

Medical Definition of aprotinin

  1. :  a polypeptide with protease-inhibiting properties formerly used to reduce blood loss and preserve platelet function during heart surgery but now withdrawn from use due to safety concerns <Based on our data, we therefore believe that additional concern is now warranted regarding the long-term safety of aprotinin among patients undergoing coronary artery bypass surgery.—Dennis T. Mangano et al., The Journal of the American Medical Association, 7 Feb. 2007>

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