Medical Definition of antibiotic lock
: a technique in which a concentrated antibiotic solution is instilled and kept within a patient's catheter for a prolonged period (such as 10 to 12 hours) to prevent or treat a catheter-related infection The antibiotic lock is aimed at decreasing intraluminal microbial colonization …—Elizabeth Krzywda et al., in The Science and Practice of Nutrition Support … , 2001 Catheters that are not easily replaced can sometimes be treated successfully with antibiotic lock therapy …—Paul L. Marino and Kenneth M. Sutin, The Little ICU Book of Facts & Formulas, 2009
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