aminoacyl-tRNA synthetase

noun

Medical Definition of aminoacyl-tRNA synthetase

: any of a class of amino-acid-specific enzymes that catalyze an ATP-driven reaction producing an ester linkage between a carboxyl group of an amino acid and a hydroxyl group of its corresponding transfer RNA to form aminoacyl-tRNA during the early stage of protein synthesis

called also aminoacyl-transfer RNA synthetase

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