amastigote

noun
amas·​ti·​gote | \ (ˈ)ā-ˈma-stə-ˌgōt How to pronounce amastigote (audio) \

Medical Definition of amastigote

: the nonmotile, parasitic form in the life cycle of some protozoans (family Trypanosomatidae, and especially genus Leishmania) that usually develops in the cells of vertebrate hosts and occurs as a minute, ovoid or spherical body with a prominent, rod-shaped kinetoplast and a rudimentary, internal flagellum arising from a basal body For all species of Leishmania, the portion of the life cycle spent in mammalian hosts is paradoxical in that the amastigote infects macrophages, the very cells of the mammalian host that constitute its primary defense against invasion by foreign organisms.— Burton J. Bogitsh et al., Human Parasitology, 2005 In the sandfly gut the amastigotes leave the host cell, transform into promastigotes, and replicate extracellularly.— David J. Wyler and Anthony R. Mattia, The New England Journal of Medicine, 17 Mar. 1994

Comments on amastigote

What made you want to look up amastigote? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

one from the Upper Peninsula of Michigan

Get Word of the Day daily email!

Test Your Vocabulary

Musical Words Quiz

  • gramophone
  • Which word describes a musical performance marked by the absence of instrumental accompaniment?
How Strong Is Your Vocabulary?

Test your vocabulary with our 10-question quiz!

TAKE THE QUIZ
Word Winder's CrossWinder

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!