Medical Definition of aconitase
: an enzyme occurring in many animal and plant tissues that accelerates the conversion of citric acid first into aconitic acid and then into isocitric acid during the Krebs cycle ◆Aconitase also functions in regulating levels of iron in the cell by inhibiting the formation of ferritin. It has an active site of iron and sulfur. … recent studies have shown that aconitase is an early target of free radical damage in stressed cells because of the presence of an iron-sulfur cluster in the enzyme.—Kyra J. Cowan, in Functional Metabolism: Regulation and Adaptation, 2004
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