aconitase

noun
acon·​i·​tase | \ ə-ˈkän-ə-ˌtās How to pronounce aconitase (audio) \

Medical Definition of aconitase

: an enzyme occurring in many animal and plant tissues that accelerates the conversion of citric acid first into aconitic acid and then into isocitric acid during the Krebs cycle

Note: Aconitase also functions in regulating levels of iron in the cell by inhibiting the formation of ferritin. It has an active site of iron and sulfur.

… recent studies have shown that aconitase is an early target of free radical damage in stressed cells because of the presence of an iron-sulfur cluster in the enzyme. — Kyra J. Cowan, in Functional Metabolism: Regulation and Adaptation, 2004

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Cite this Entry

“Aconitase.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/aconitase. Accessed 20 Jan. 2021.

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