Medical Dictionary

aconitase

noun acon·i·tase \ ə-ˈkän-ə-ˌtās \

medical Definition of aconitase

: an enzyme occurring in many animal and plant tissues that accelerates the conversion of citric acid first into aconitic acid and then into isocitric acid during the Krebs cycle
Note: Aconitase also functions in regulating levels of iron in the cell by inhibiting the formation of ferritin. It has an active site of iron and sulfur.
  • … recent studies have shown that aconitase is an early target of free radical damage in stressed cells because of the presence of an iron-sulfur cluster in the enzyme.
  • —Kyra J. Cowan, in Functional Metabolism: Regulation and Adaptation2004

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