Wolfram syndrome

noun
Wol·fram syndrome | \ ˈwu̇l-frəm- \
variants: or Wolfram's syndrome

Medical Definition of Wolfram syndrome 

: a rare hereditary disorder that is characterized especially by type 1 diabetes, diabetes insipidus, optic atrophy, sensorineural deafness, and bladder dysfunction and that is inherited as an autosomal recessive trait

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occurring twice a year or every two years

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