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Sim·plex·vi·rus | \ ˈsim-ˌpleks-ˌvī-rəs 
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\Medical Definition of Simplexvirus
: a genus of double-stranded DNA viruses of the family Herpesviridae that usually infect primates including two (HSV-1 and HSV-2) specific for humans and that tend to persist in the host as latent infections in neurons
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