Medical Dictionary

Sandhoff's disease

noun Sand·hoff's disease \ ˈsand-ˌhȯfs- \
variants: or Sandhoff disease play \-ˌhȯf-\

medical Definition of Sandhoff's disease

:a hereditary disorder of lipid metabolism that is closely related to or a variant of Tay-Sachs disease, typically affects individuals of non-Jewish ancestry, and is characterized by great reduction in or absence of both hexosaminidase A and hexosaminidase B

Biographical Note for sandhoff's disease

  • Sandhoff, K.,, Andreae play \än-ˈdrā-e\, U., and Jatzkewitz \ˈyäts-kə-ˌvits\, H. German medical scientists. Sandhoff, Andreae, and Jatzkewitz jointly published a description of a variant form of Tay-Sachs disease in 1968. They based their report on three typical cases of Tay-Sachs, one exceptional case, and seven controls.

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