Medical Dictionary

Sandhoff's disease

play
noun Sand·hoff's disease \ˈsand-ˌhȯfs-\
variants: or

Sandhoff disease

\-ˌhȯf-\play

Medical Definition of Sandhoff's disease

  1. :  a hereditary disorder of lipid metabolism that is closely related to or a variant of Tay-Sachs disease, typically affects individuals of non-Jewish ancestry, and is characterized by great reduction in or absence of both hexosaminidase A and hexosaminidase B

Biographical Note for sandhoff's disease

Sandhoff

,

K.,

Andreae

\än-ˈdrā-e\play ,

U.,

, and

Jatzkewitz

\ˈyäts-kə-ˌvits\,

H.

, German medical scientists. Sandhoff, Andreae, and Jatzkewitz jointly published a description of a variant form of Tay-Sachs disease in 1968. They based their report on three typical cases of Tay-Sachs, one exceptional case, and seven controls.


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