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Sand·hoff's disease | \ ˈsand-ˌhȯfs- 
\
\variants:
or Sandhoff disease \ -ˌhȯf- \
\Medical Definition of Sandhoff's disease
: a hereditary disorder of lipid metabolism that is closely related to or a variant of Tay-Sachs disease, typically affects individuals of non-Jewish ancestry, and is characterized by great reduction in or absence of both hexosaminidase A and hexosaminidase B
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