Sandhoff's disease

noun
Sand·hoff's disease | \ˈsand-ˌhȯfs- \
variants: or Sandhoff disease \-ˌhȯf- \

Medical Definition of Sandhoff's disease 

: a hereditary disorder of lipid metabolism that is closely related to or a variant of Tay-Sachs disease, typically affects individuals of non-Jewish ancestry, and is characterized by great reduction in or absence of both hexosaminidase A and hexosaminidase B

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