plural STIs
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Word History

Etymology

sexually transmitted infection

First Known Use

1983, in the meaning defined above

Time Traveler
The first known use of STI was in 1983

Browse Nearby Words

Cite this Entry

“STI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/STI. Accessed 6 Nov. 2025.

Medical Definition

STI

abbreviation or noun
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Last Updated: - Entry added
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