Medical Dictionary

Rendu–Osler–Weber disease

noun Ren·du–Os·ler–Web·er disease \ˌrän-ˌd(y)ü-ˈäs-lər-ˈweb-ər-\
variants: or

Rendu–Osler–Weber syndrome

Medical Definition of Rendu–Osler–Weber disease

Biographical Note for rendu–osler–weber disease


\räⁿ-du̅e̅\play ,


(1844–1902), French physician. Rendu was the leading French clinician of his day. His major writings include monographs on dysfunctions of the heart and liver and on chronic nephritis. In 1888 he described a form of hysterical tremor that is precipitated or aggravated by volitional movements. Eight years later he published a report of a single case of hereditary hemorrhagic telangiectasia. Additional cases and information were supplied by Sir William Osler in 1901 and by Frederick Parkes Weber in 1907.



Sir William

(1849–1919), American physician. Osler was the greatest clinician and arguably the most famous and revered physician of his time. He held successive professorships in medicine at McGill University in Montreal, at the University of Pennsylvania in Philadelphia, and, most importantly, at Johns Hopkins University in Baltimore. During his 16 years there he became enormously skillful and celebrated as a teacher of medicine. He modeled the clinical and tutorial practice after European schools and did much to establish Hopkins as the premier medical school in the United States Osler did research on cardiovascular diseases and anatomy, blood platelets, typhoid fever, malaria, pneumonia, amebiasis, tuberculosis, and gallstones. In 1892 he published a text on the principles and practice of medicine that dominated the field for the next 30 years. The book is credited with inspiring the founding of the Rockefeller Institute for Medical Research and the Rockefeller Foundation. After his tenure at Hopkins he accepted a professorship at Oxford University. He was among the founders of the Royal Society of Medicine in 1907, and he was widely known as a medical historian.

F. P. Weber

, —see weber-christian disease

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