Philadelphia chromosome

noun
Phil·​a·​del·​phia chromosome | \ ˌfil-ə-ˈdel-fē-ə- How to pronounce Philadelphia chromosome (audio) \

Medical Definition of Philadelphia chromosome

: an abnormally short chromosome 22 that is found in the hematopoietic cells of persons affected with chronic myelogenous leukemia and lacks the major part of its long arm which has usually undergone translocation to chromosome 9 A bone marrow test the next day revealed a genetic abnormality called the Philadelphia chromosome that is the signature of chronic myelogenous leukemia, or C.M.L., a blood cell cancer that in the last decade has been transformed from ultimately fatal to nearly always treatable …— Jane E. Brody, The New York Times, 19 Jan. 2010 Scientists have continued to hammer away at the so-called Philadelphia chromosome, a shortened chromosome 22. They now know that it results when chromosomes 9 and 22 exchange genetic material.— Nathan Seppa, Science News, 11 Dec. 1999

Comments on Philadelphia chromosome

What made you want to look up Philadelphia chromosome? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

an enemy or opponent

Get Word of the Day daily email!

Test Your Vocabulary

Name That Thing: Animal Edition

  • alt 5a023732e6f75
  • Name that animal:
True or False

Test your knowledge - and maybe learn something along the way.

TAKE THE QUIZ
Citation

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!