: a synthetic amino acid C5H9NO4 that binds selectively to a subset of glutamate receptors on neurons where the binding of glutamate results in the opening of calcium channels

Examples of NMDA in a Sentence

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Memantine Memantine works by preventing glutamate from attaching to the N-methyl-D-aspartate (NMDA) receptor (binding site). Ross Phan, Verywell Health, 12 Aug. 2025 Both the anesthetic and potential neuroprotective effects occur because xenon can bind to brain receptors called N-methyl-D-aspartate (NMDA) receptors. Stephanie Pappas, Scientific American, 29 May 2025

Word History

Etymology

N-methyl-D-aspartate

First Known Use

1986, in the meaning defined above

Time Traveler
The first known use of NMDA was in 1986

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Cite this Entry

“NMDA.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/NMDA. Accessed 10 Sep. 2025.

Medical Definition

: a synthetic amino acid C5H9NO4 that binds selectively to a subset of glutamate receptors on neurons where the binding of glutamate results in the opening of calcium channels

called also N-methyl-D-aspartate

Last Updated: - Updated example sentences
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