SINCE 1828
Letterer-Siwe disease
noun
Let·ter·er-Si·we disease
| \ ˈlet-ər-ər-ˈsē-və-
\
\
Medical Definition of Letterer-Siwe disease
: an acute often fatal disease of young children that is marked by proliferation of Langerhans cells and is characterized especially by fever, anemia, hepatosplenomegaly, and a eczematous skin rash
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