To save this word, you'll need to log in.
Let·ter·er-Si·we disease | \ ˈlet-ər-ər-ˈsē-və- 
\
\Medical Definition of Letterer-Siwe disease
: an acute often fatal disease of young children that is marked by proliferation of Langerhans cells and is characterized especially by fever, anemia, hepatosplenomegaly, and a eczematous skin rash
Comments on Letterer-Siwe disease
What made you want to look up Letterer-Siwe disease? Please tell us where you read or heard it (including the quote, if possible).
Test Your Vocabulary
More Confusing Words—Quiz
- The magician
______moved the selected card to the top of the deck.
Can you spell these 10 commonly misspelled words?
TAKE THE QUIZ
Test Your Knowledge - and learn some interesting things along the way.
TAKE THE QUIZLove words? Need even more definitions?
Merriam-Webster unabridgedWords at Play
Ask the Editors
Word Games
- More Confusing Words—Quiz
How many of these commonly confused words do you know?
Take the quiz - Name that Thing: Toys and Games Edition
It's all fun and games until someone beats your high score.
Take the quiz - Spell It
Can you spell these 10 commonly misspelled words?
Take the quiz - Bee Cubed
Listen to the words and spell through all three levels.
Play the game
Share Letterer-Siwe disease