Medical Definition of Letterer–Siwe disease
: an acute often fatal disease of young children that is marked by proliferation of Langerhans cells and is characterized especially by fever, anemia, hepatosplenomegaly, and a eczematous skin rash
Biographical Note for letterer–siwe disease
Erich (1895–1982), German physician. Letterer first described Letterer-Siwe disease in 1924. The author of several textbooks on pathology, he described the disease from the viewpoint of a pathologist.
Sture August (1897–1966), Swedish pediatrician. Siwe presented another, independent description of Letterer-Siwe disease in 1933, this time from the clinical point of view.
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