Medical Definition of Lennox–Gastaut syndrome
: an epileptic syndrome especially of young children that is marked by several seizure types and especially tonic, atonic, and atypical absence seizures, is associated with mild to severe impairment in intellectual functioning, may be idiopathic or have an identifiable cause (as tuberous sclerosis, brain malformation, brain damage resulting from asphyxia during birth or meningitis, or metabolic disease), and is characterized between seizures by an EEG having a slow spike and wave pattern
Biographical Note for lennox–gastaut syndrome
William Gordon (1884–1960), American neurologist. Lennox served for many years on the neurology faculty at Harvard University Medical School. Concurrently he was on the staff of Boston's Children's Hospital, serving as chief of the Seizure Division from 1947. In 1939 he organized the National Epilepsy League, a lay organization devoted to combating societal discrimination against epileptics. He devoted his career to researching epilepsy and migraine, focusing on such topics as blood chemistry, cerebral circulation, the electrical activity of the brain, and metabolism. With Frederic A. Gibbs he demonstrated the value of electroencephalography in the diagnosis and treatment of epilepsy. He is also credited with establishing the effectiveness of trimethadione in the treatment of absence seizures in children. He published numerous books and articles on epilepsy, including Epilepsy and Related Disorders (1960), in which he described Lennox-Gastaut syndrome.
Henri Jean–Pascal (1915–1995), French neurologist. Gastaut served on the medical faculty of Marseilles University, eventually becoming its dean. He also acted as chief neurobiologist for public hospitals in Marseilles. From the early 1960s he was director of the Regional Center for Epileptic Children and director of the neurobiological research unit at the National Institutes of Health. His research centered on electroencephalography and epilepsy. The author of many books, monographs, and articles, he published the first description of what is now known as Lennox-Gastaut syndrome in 1957 in an article coauthored with M. Vigoroux, C. Trevisan, and H. Regis.
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