Hirsch·sprung's disease | \ ˈhirsh-ˌpru̇ŋz- 
\
\Medical Definition of Hirschsprung's disease
: megacolon that is caused by congenital absence of ganglion cells in the muscular wall of the distal part of the colon with resulting loss of peristaltic function in this part and dilatation of the colon proximal to the aganglionic part
— called also congenital megacolon
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