Medical Dictionary

Henderson-Hasselbalch equation

noun Hen·der·son-Has·sel·balch equation \ ˈhen-dər-sən-ˈhas-əl-ˌbälk- \

medical Definition of Henderson-Hasselbalch equation

:an equation that equates the pH of a buffered solution (as the blood) to the sum of the cologarithm (p) of the dissociation constant (K) of the acid in the buffer and the logarithm of the ratio of the concentration ([ ]) of the salt to that of the acid and that is written

Biographical Note for henderson-hasselbalch equation

  • Hasselbalch, Karl Albert (1874–1962), Danish biochemist. In 1916 Hasselbalch converted the equation developed by Lawrence Henderson into logarithmic form. Although the Henderson-Hasselbalch equation is only approximately true, it still remains the most useful mathematical model for treating problems dealing with buffer solutions.

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