Hartnup (flourished 1950s),
British family. Hartnup disease was first described in 1956 in an article published under the names of D. N. Baron, C. E. Dent, H. Harris, E. W. Hart, and J. B. Jepson; all were physicians at London hospitals. The clinical studies of Hartnup disease began in 1951 when a 12-year-old male member of the Hartnup family was admitted to a London hospital under the care of E. W. Hart. At first it was thought that he was suffering from severe pellagra associated with a neurological disorder. Detailed investigation and experimental treatment of his case over several years gradually led his physicians to the realization that they were dealing with a distinct and previously undescribed syndrome. Studies of the other members of the family revealed that Hartnup disease is an inherited metabolic disease. The disease affected four out of eight offspring of a marriage between first cousins.