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Hart·nup disease | \ ˈhärt-ˌnəp- 
\
\Medical Definition of Hartnup disease
: an inherited metabolic disease that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum
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