Gard·ner's syndrome | \ ˈgärd-nərz- 
\
\Medical Definition of Gardner's syndrome
: a familial polyposis that is characterized by numerous adenomatous polyps in the colon which typically become malignant if left untreated, by osteomas (as of the skull or mandible), and by skin tumors, that is inherited as an autosomal dominant trait, and that is sometimes considered a variant form of familial adenomatous polyposis
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