Medical Definition of DiGeorge syndrome
: a rare congenital disease that is characterized especially by absent or underdeveloped thymus and parathyroid glands, heart defects, immunodeficiency, hypocalcemia, and characteristic facial features (as wide-set eyes, small jaws, and low-set ears) and is typically caused by a deletion on the chromosome numbered 22
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Merriam-Webster unabridged
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