Medical Dictionary

Creutzfeldt–Jakob disease

noun Creutz·feldt–Ja·kob disease
variants: also

Creutzfeld–Jakob disease


Medical Definition of Creutzfeldt–Jakob disease

  1. :  a rare progressive fatal prion disease marked by the development of porous brain tissue, premature dementia in middle age, and gradual loss of muscular coordination—abbreviation CJD; called also Jakob-Creutzfeldt disease; see variant creutzfeldt-jakob disease

Biographical Note for creutzfeldt–jakob disease



Hans Gerhard

(1885–1964), and



Alfons Maria

(1884–1931), German psychiatrists. Creutzfeldt published his description of the disease now known as Creutzfeldt-Jakob disease in 1920. A year later in the same neurological journal Jakob offered his description. Although Creutzfeldt's description is the original one, Jakob's is the better known of the two, so the disease is named in honor of both men.

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