Medical Dictionary

Castleman's disease

noun Cas·tle·man's disease \ˈkas-əl-mənz-\
variants: or

Castleman disease

Medical Definition of Castleman's disease

  1. :  a lymphoproliferative disorder characterized by enlargement of the lymph nodes due to benign overgrowth of lymphoid tissue Castleman's disease usually appears as a localized, often asymptomatic, lymphoid mass in a single lymph node, and rarely as a systemic illness that affects multiple lymph nodes and is marked especially by fever, weight loss, and fatigue. Patients with localized Castleman's disease can be treated with surgical removal or radiation therapy.—Phillip J. Bierman et al., in Cecil Textbook of Medicine, 22nd edition, 2004 Multicentric Castleman's disease causes lymphadenopathy, but systemic symptoms, including fevers with high temperatures, are also common and were not prominent in this case.—Rajesh T. Gandhi et al., The New England Journal of Medicine, 25 Dec. 2014—called also angiofollicular lymph node hyperplasia, giant lymph node hyperplasia

Biographical Note for castleman's disease




(1906–1982), American pathologist. Castleman spent most of his career at Boston's Massachusetts General Hospital. He became head of the hospital's division of anatomic pathology, while concurrently serving as professor of pathology at Harvard Medical School. From 1951 to 1975 he was editor of case records for Massachusetts General. He was known for his clinicopathologic investigations of parathyroid disease, and his work formed the basis for modern-day surgical treatment of hyperparathyroidism. He was credited as the author or coauthor on more than 100 papers on a variety of disorders. In 1954 he described what is now known as Castleman's disease.

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to cast off or become cast off

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