von Willebrand factor

noun

Definition of von Willebrand factor

: a large glycoprotein clotting factor circulating in blood plasma that mediates platelet adhesion to collagen at sites of vascular injury, that binds to and protects factor VIII from degradation, and that is deficient or defective in individuals affected with von Willebrand disease called also VW factor
Note: Von Willebrand factor is synthesized in endothelial cells of blood vessels and in megakaryocytes of bone marrow.

Origin and Etymology of von willebrand factor

after Erik Adolf von Willebrand †1949 Finnish physician


Medical Dictionary

von Willebrand factor

noun von Wil·le·brand factor \ vän-ˈvil-ə-ˌbränt- \

medical Definition of von Willebrand factor

: a large glycoprotein clotting factor circulating in blood plasma that mediates platelet adhesion to collagen at sites of vascular injury, that binds to and protects factor VIII from degradation, and that is deficient or defective in individuals affected with von Willebrand disease
  • Patients are deficient in the von Willebrand factor, one of the many blood-clotting proteins.
  • —Paul G. DonohueThe Springfield (Massachusetts) Union-News6 July 1994
Note: Von Willebrand factor is synthesized in endothelial cells of blood vessels and in megakaryocytes of bone marrow.
called also VW factor

Biographical Note for von willebrand factor

  • Willebrand, Erik Adolf von (1870–1949), Finnish physician. He described von Willebrand's disease first in 1926 and again in 1931 in a follow-up article.

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