von Willebrand factor

noun

: a large glycoprotein clotting factor circulating in blood plasma that mediates platelet adhesion to collagen at sites of vascular injury, that binds to and protects factor VIII from degradation, and that is deficient or defective in individuals affected with von Willebrand disease

called also VW factor

Note: Von Willebrand factor is synthesized in endothelial cells of blood vessels and in megakaryocytes of bone marrow.

Word History

Etymology

after Erik Adolf von Willebrand †1949 Finnish physician

First Known Use

1970, in the meaning defined above

Time Traveler
The first known use of von Willebrand factor was in 1970

Dictionary Entries Near von Willebrand factor

Cite this Entry

“Von Willebrand factor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/von%20Willebrand%20factor. Accessed 6 Feb. 2023.

Medical Definition

von Willebrand factor

noun
von Wil·​le·​brand factor vän-ˈvil-ə-ˌbränt- How to pronounce von Willebrand factor (audio)
: a large glycoprotein clotting factor circulating in blood plasma that mediates platelet adhesion to collagen at sites of vascular injury, that binds to and protects factor VIII from degradation, and that is deficient or defective in individuals affected with von Willebrand disease
Patients are deficient in the von Willebrand factor, one of the many blood-clotting proteins.Paul G. Donohue, The Springfield (Massachusetts) Union-News

Note: Von Willebrand factor is synthesized in endothelial cells of blood vessels and in megakaryocytes of bone marrow.

called also VW factor

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