tumor necrosis factor

noun

Definition of tumor necrosis factor

: a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins and that mediates inflammation and induces the destruction of some tumor cells and the activation of white blood cells

Examples of tumor necrosis factor in a Sentence

Recent Examples on the Web Pillai’s team found that lymph nodes in the COVID-19 deaths had a large increase in the amount of one of these cytokines, tumor necrosis factor alpha (TNF-α), in comparison with the control autopsies. Jon Cohen, Science | AAAS, "The coronavirus may shut down the immune system’s vital classrooms," 25 Aug. 2020 Many older people have increased concentrations of proinflammatory cytokines such as tumor necrosis factor (TNF), suggesting that a slight inflammatory state exists throughout the body at this point in life. Kenneth S. Kosik, Scientific American, "Five Types of Research, Underexplored until Recently, Could Produce Alzheimer’s Treatments," 20 Apr. 2020 Apart from a surge in interleukin-6, the body may also show high swirling levels of molecules called interleukin-1, interferon-gamma, C-reactive protein and tumor necrosis factor-alpha. Apoorva Mandavilli, New York Times, "The Coronavirus Patients Betrayed by Their Own Immune Systems," 1 Apr. 2020 However, tumor necrosis factor alpha, another key response to acute injury that can also cause problems long term, did not change, the study found. Sandee Lamotte, CNN, "Another win for optimism! Recovery after stroke," 12 Feb. 2020 In psoriasis, these overactive cells can lead to elevated levels of tumor necrosis factor, which is secreted via the inflammatory process. Sun Pharmaceuticals, WIRED, "IL-23: The Master Regulator Behind Plaque Psoriasis," 30 Oct. 2019 The first generation of these drugs were TNF-alpha agents that targeted the tumor necrosis factor to limit the immune response. Sun Pharmaceuticals, WIRED, "IL-23: The Master Regulator Behind Plaque Psoriasis," 30 Oct. 2019 Enbrel is known as a tumor necrosis factor (or TNF) blocker. John Fauber, Milwaukee Journal Sentinel, "A drug's most dangerous side effects often aren't discovered until it's on the market," 18 July 2019 Those proteins, called tumor necrosis factor (TNF) and interleukin-22 (IL-22). William Herkewitz, Popular Mechanics, "Engineered Cells Can Create Medicine Inside Your Body," 17 Dec. 2015

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'tumor necrosis factor.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of tumor necrosis factor

1975, in the meaning defined above

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The first known use of tumor necrosis factor was in 1975

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Cite this Entry

“Tumor necrosis factor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/tumor%20necrosis%20factor. Accessed 4 Dec. 2020.

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More Definitions for tumor necrosis factor

tumor necrosis factor

noun

Medical Definition of tumor necrosis factor

: a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins, that mediates inflammation, and that induces the destruction of some tumor cells and the activation of white blood cells abbreviation TNF

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