tumor necrosis factor

noun

: a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins and that mediates inflammation and induces the destruction of some tumor cells and the activation of white blood cells

Examples of tumor necrosis factor in a Sentence

Recent Examples on the Web Unlike some traditional ulcerative colitis therapies like tumor necrosis factor (TNF) blockers, Skyrizi is less likely to cause severe side effects. Alyssa Hui, Verywell Health, 28 June 2024 The second is tumor necrosis factor-alpha (TNF-alpha). William A. Haseltine, Forbes, 20 Feb. 2023 High levels of inflammatory markers like interleukin 6 and tumor necrosis factor inhibit the natural rhythm of the sleep-wake cycle, Wirth says. Erin Prater, Fortune Well, 18 Mar. 2023 Three cell-signaling molecules—tumor necrosis factor alpha, interleukin 6 and interferon beta—stood out in long COVID patients. Stephani Sutherland, Scientific American, 14 Feb. 2023 The liberation of tumor necrosis factor and immune-stimulating cytokines by metalloproteases and the release of bioactive lipids by phospholipases cause immune cells to rush to the wound. Christie Wilcox, Discover Magazine, 19 Apr. 2016 Both of these drugs work by interfering with an immune system molecule called tumor necrosis factor, or TNF. Markham Heid, Time, 10 Jan. 2023 The new study, which was presented in March at a virtual meeting of the American Physical Society, focused on the effects of a signaling molecule called tumor necrosis factor alpha, or TNF. Nala Rogers, Discover Magazine, 2 June 2021 One protein that stood out in the study was tumor necrosis factor alpha, which is made by the immune system to regulate inflammation. Sandee Lamotte, CNN, 5 Apr. 2022

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'tumor necrosis factor.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1975, in the meaning defined above

Time Traveler
The first known use of tumor necrosis factor was in 1975

Dictionary Entries Near tumor necrosis factor

Cite this Entry

“Tumor necrosis factor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/tumor%20necrosis%20factor. Accessed 22 Jul. 2024.

Medical Definition

tumor necrosis factor

noun
: a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins, that mediates inflammation, and that induces the destruction of some tumor cells and the activation of white blood cells
abbreviation TNF
Last Updated: - Updated example sentences
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