tumor necrosis factor

noun

Definition of tumor necrosis factor

: a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins and that mediates inflammation and induces the destruction of some tumor cells and the activation of white blood cells

Examples of tumor necrosis factor in a Sentence

Recent Examples on the Web For example, your doctor might suggest an anti-tumor necrosis factor drug that blocks a protein called TNF-alpha that promotes inflammation. Jennifer Larson, SELF, 3 Nov. 2021 The other is the pathway that triggers inflammation through proinflammatory cytokines like tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8). William A. Haseltine, Forbes, 1 Nov. 2021 Several targeted therapies focus on a particularly powerful cytokine called tumor necrosis factor, or TNF. Marla Broadfoot, Scientific American, 1 Sep. 2021 Furthermore, the agency has limited the drug’s use to patients who’ve tried but failed on at least one tumor necrosis factor inhibitor. Trefis Team, Forbes, 7 Sep. 2021 These prevent the tumor necrosis factor protein from binding to its corresponding receptors and causing inflammation8. Stephanie Watso, SELF, 27 Aug. 2021 Infliximab is an antibody given as a single infusion that blocks tumor necrosis factor alpha, a pivotal signaling molecule in the immune system, and is used to treat autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Kai Kupferschmidt, Science | AAAS, 5 Aug. 2021 The researchers also hope to test an inhibitor of tumor necrosis factor, which is involved in inflammation, and another drug that inhibits the complement system, an arm of the immune system. Kai Kupferschmidt, Science | AAAS, 3 Mar. 2021 Pillai’s team found that lymph nodes in the COVID-19 deaths had a large increase in the amount of one of these cytokines, tumor necrosis factor alpha (TNF-α), in comparison with the control autopsies. Jon Cohen, Science | AAAS, 25 Aug. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'tumor necrosis factor.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of tumor necrosis factor

1975, in the meaning defined above

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The first known use of tumor necrosis factor was in 1975

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Dictionary Entries Near tumor necrosis factor

tumorigenic

tumor necrosis factor

tumorous

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Cite this Entry

“Tumor necrosis factor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/tumor%20necrosis%20factor. Accessed 27 Jan. 2022.

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More Definitions for tumor necrosis factor

tumor necrosis factor

noun

Medical Definition of tumor necrosis factor

: a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins, that mediates inflammation, and that induces the destruction of some tumor cells and the activation of white blood cells abbreviation TNF

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