: an act or instance of perforating the skull with a surgical instrument

Examples of trephination in a Sentence

Recent Examples on the Web
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The brother who received the trephination died soon after, the study concluded, as the bones showed no signs of healing. Matt Hrodey, Discover Magazine, 23 Feb. 2023 Having a hole surgically bored into your skull is called trephination, and it’s considered the world’s first form of surgery. Washington Post, 5 Aug. 2021 The Woman's skull is a fine example of trephination - the practice of deliberately cutting holes in the skull. Neuroskeptic, Discover Magazine, 23 Mar. 2012 Roughly two-thirds of the skulls that have been found bearing trephination marks also show evidence of subsequent bone healing. Amy Barth, Discover Magazine, 26 Apr. 2010

Word History

Etymology

trephine + -ation

First Known Use

1874, in the meaning defined above

Time Traveler
The first known use of trephination was in 1874

Browse Nearby Words

Cite this Entry

“Trephination.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/trephination. Accessed 28 Jul. 2026.

Medical Definition

trephination

noun
: an act or instance of using a trephine (as to perforate the skull)
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