traz·​o·​done ˈtra-zə-ˌdōn How to pronounce trazodone (audio)
: an antidepressant drug C19H22ClN5O administered in the form of its hydrochloride

Examples of trazodone in a Sentence

Recent Examples on the Web His death was ruled an accident caused by fentanyl and trazodone toxicity, according to the medical examiner. Harriet Ramos, Fort Worth Star-Telegram, 16 Feb. 2024 Three drugs were also found in Selena’s system that may have contributed to her death: THC, the psychoactive ingredient in marijuana; trazodone, an antidepressant; and cyclobenzaprine, a muscle relaxant. Jeremy Childs, Los Angeles Times, 12 Jan. 2024 Kennedy recommends acepromazine, dexmedetomidine and trazodone, which are all prescription medications. Emma Fox, Los Angeles Times, 30 June 2023 After my husband passed away, a doctor prescribed trazodone. Joe and Teresa Graedon, oregonlive, 26 June 2023 Another drug Clancy was prescribed called trazodone (often used in small doses for insomnia), shares many properties with SSRIs but is in a separate class of drugs called serotonin receptor antagonists and reuptake inhibitors, or SARIs. Jessica Bartlett,, 3 Feb. 2023 Prescription medications: These include trazodone, zolpidem (Ambien), eszopiclone (Lunesta), and ramelteon (Rozerem). Amber Smith, Discover Magazine, 12 Oct. 2022 Gil was taking the antidepressant trazodone, medical records show. Kelly Davis, San Diego Union-Tribune, 4 Apr. 2022 Although non-prescription melatonin is by far the most popular, some children are prescribed epilepsy drugs, sedatives, alpha agonists such as clonidine or antidepressants such as trazodone, depending on the nature of their problem. Claudia Wallis, Scientific American, 18 Nov. 2017

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'trazodone.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


perhaps from International Scientific Vocabulary triazo azido + pyridine + -one

First Known Use

1971, in the meaning defined above

Time Traveler
The first known use of trazodone was in 1971

Dictionary Entries Near trazodone

Cite this Entry

“Trazodone.” Dictionary, Merriam-Webster, Accessed 16 Jun. 2024.

Medical Definition


traz·​o·​done ˈtraz-ə-ˌdōn How to pronounce trazodone (audio)
: an antidepressant drug that is administered in the form of its hydrochloride C19H22ClN5O·HCl and inhibits the uptake of serotonin by the brain

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