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These tRNA modifications can be a key driver of cancer and resistance to chemotherapy, and they are also linked to developmental and neurological diseases.—
Marlene Belfort,
The Conversation,
10 Feb. 2026 Lovisa Afzelius, an origination partner at Flagship Pioneering and chief executive of Alltrna, says the company could potentially use a single tRNA drug to treat thousands of diseases that stem from the same genetic mutation.—BostonGlobe.com,
9 Nov. 2021 To find out, the team compared Klosneuvirus’s aminoacyl tRNA synthetase sequences with other forms of the enzymes across the tree of life.—
Jeffrey Marlow,
Discover Magazine,
20 Apr. 2017 For example, most viruses lack aminoacyl tRNA synthetase enzymes, which shuttle amino acids onto transfer RNA molecules; these in turn make their way to the ribosome, dropping off their cargo to build proteins from the chains of amino acids.—
Jeffrey Marlow,
Discover Magazine,
20 Apr. 2017