First Known Use of spherule
Medical Definition of spherule
: a thick-walled spherical structure enclosing endospores and occurring in the parasitic form of fungi of the genus Coccidioides Histopathological examination revealed spherules that were consistent with coccidioides species and focal organizing pneumonia with eosinophilia.—Holenarasipur R. Vikram et al., The New England Journal of Medicine, 2 June 2011
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