spher·​ule ˈsfir-ül How to pronounce spherule (audio)
-ˌyül How to pronounce spherule (audio)
: a little sphere or spherical body

Word History

First Known Use

1665, in the meaning defined above

Time Traveler
The first known use of spherule was in 1665

Dictionary Entries Near spherule

Cite this Entry

“Spherule.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/spherule. Accessed 27 May. 2023.

Medical Definition


: a thick-walled spherical structure enclosing endospores and occurring in the parasitic form of fungi of the genus Coccidioides
Histopathological examination revealed spherules that were consistent with coccidioides species and focal organizing pneumonia with eosinophilia.Holenarasipur R. Vikram et al., The New England Journal of Medicine
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