ris·​per·​i·​done ri-ˈsper-ə-ˌdōn How to pronounce risperidone (audio)
: an antipsychotic drug C28H27FN4O2 used especially to treat schizophrenia

Example Sentences

Recent Examples on the Web Some common first-generation antipsychotics include chlorpromazine, haloperidol, perphenazine, and fluphenazine; second-generation drugs include olanzapine, risperidone, quetiapine, aripiprazole, ziprasidone, lurasidone, cariprazine, and paliperidone. Ashley Abramson, SELF, 11 Feb. 2022 Neither cognitive therapy, nor the antipsychotic drug risperidone (at a low dose) had any effect: those given 'supportive therapy' (basically: sympathetic chats) and a placebo pill did just as well. Neuroskeptic, Discover Magazine, 16 Dec. 2012 The patient agreed to a risperidone [an antipsychotic] trial of up to 2 mg per day. Neuroskeptic, Discover Magazine, 19 Feb. 2011 Over the years, Maguire has conducted small, successful clinical studies with these medications including risperidone, olanzapine and lurasidone. Amber Dance Knowable Magazine, Smithsonian Magazine, 4 Sep. 2020 Her doctor immediately started her on an antidepressant and on risperidone (Risperdal), an antipsychotic. Andrea Alfano, Scientific American, 1 July 2015 Unlike risperidone, though, aripiprazole has not been shown to work long term in children with autism. Popular Science, 10 Mar. 2020 For that reason, the drug was expected to cause fewer side effects than risperidone. Popular Science, 10 Mar. 2020 Antipsychotic medications like haloperidol and risperidone, which are often given for anxiety and agitation, can increase the risk of death in people with dementia. Andrea Petersen, New York Times, 8 Dec. 2019 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'risperidone.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


perhaps from fluor- + is- + piperidine + -one

First Known Use

1988, in the meaning defined above

Time Traveler
The first known use of risperidone was in 1988

Dictionary Entries Near risperidone

Cite this Entry

“Risperidone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/risperidone. Accessed 8 Jun. 2023.

Medical Definition


ris·​per·​i·​done ri-ˈsper-ə-ˌdōn How to pronounce risperidone (audio)
: an antipsychotic drug C28H27FN4O2 that is used especially to treat schizophrenia, acute manic episodes of bipolar disorder, and irritability associated with autism in children and adolescents

Note: Risperidone's exact mechanism of action is unknown, but it is noted for its affinity for certain serotonin, dopamine, alpha-adrenergic, and histamine receptors in the brain. It is marketed under the trademark Risperdal.

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