restriction enzyme

noun

: any of various enzymes that cleave DNA into fragments at specific sites in the interior of the molecule

called also restriction endonuclease

Examples of restriction enzyme in a Sentence

Recent Examples on the Web
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The Application of Restriction Enzymes - Researchers use restriction enzymes such as BsaI and BsmBI to cut coronavirus genomes into manageable pieces, enabling the assembly of synthetic infectious clones by growing separate genome fragments in bacteria and later rejoining them. Steve Brozak, Forbes.com, 9 June 2026 Crichton goes on to re-create the display of a Cray X-MP supercomputer, which identifies a DNA error that will be repaired with restriction enzymes. Cal Newport, The New Yorker, 29 Jan. 2025 In the 1970s, molecular biologists figured out how to use restriction enzymes to cut DNA, giving birth to the modern biotechnology industry. Quanta Magazine, 6 Feb. 2015

Word History

First Known Use

1965, in the meaning defined above

Time Traveler
The first known use of restriction enzyme was in 1965

Cite this Entry

“Restriction enzyme.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/restriction%20enzyme. Accessed 26 Jun. 2026.

Medical Definition

restriction enzyme

noun
: any of various enzymes that cleave DNA into fragments at specific sites in the interior of the molecule and are often used as tools in molecular analysis

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