restriction enzyme

noun

: any of various enzymes that cleave DNA into fragments at specific sites in the interior of the molecule

called also restriction endonuclease

Examples of restriction enzyme in a Sentence

Recent Examples on the Web
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Crichton goes on to re-create the display of a Cray X-MP supercomputer, which identifies a DNA error that will be repaired with restriction enzymes. — Cal Newport, The New Yorker, 29 Jan. 2025 Some microbes defend themselves from invasion by using molecules known as restriction enzymes. — Quanta Magazine, 6 Feb. 2015

Word History

First Known Use

1965, in the meaning defined above

Time Traveler
The first known use of restriction enzyme was in 1965

Cite this Entry

“Restriction enzyme.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/restriction%20enzyme. Accessed 28 Sep. 2026.

Medical Definition

restriction enzyme

noun
: any of various enzymes that cleave DNA into fragments at specific sites in the interior of the molecule and are often used as tools in molecular analysis

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