protease inhibitor

noun

: a substance that inhibits the action of a protease
specifically : any of various drugs (such as indinavir) that inhibit the action of the protease of HIV so that the cleavage of viral proteins into mature functional infectious particles is prevented and that are used especially in combination with other agents in the treatment of HIV infection

Examples of protease inhibitor in a Sentence

Recent Examples on the Web
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The filing also details the company's ongoing litigation with Pfizer regarding a patent infringement suit related to a coronavirus protease inhibitor. Quartz Intelligence Newsroom, Quartz, 12 Feb. 2025 The challenges that remain By the late 1990s, the availability of protease inhibitors led AIDS death rates in the U.S. to plummet. Marc Ramirez, USA TODAY, 12 Oct. 2024 Later that year, the F.D.A. evaluated a new protease inhibitor that was still in early-stage trials. Gideon Lewis-Kraus, The New Yorker, 19 June 2023 In 1999, a French study first confirmed that hair loss was a side effect of men using the protease inhibitor Crixivan (indinavir). Emily Rekstis, Allure, 26 Oct. 2022 See All Example Sentences for protease inhibitor

Word History

First Known Use

1943, in the meaning defined above

Time Traveler
The first known use of protease inhibitor was in 1943

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Cite this Entry

“Protease inhibitor.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/protease%20inhibitor. Accessed 8 Sep. 2025.

Medical Definition

protease inhibitor

noun
: a substance that inhibits the action of a protease
specifically : any of various drugs (as indinavir or saquinavir) that inhibit the action of HIV protease so that cleavage of viral proteins into mature infectious particles is prevented and that are used especially in combination with other antiretroviral agents in the treatment of HIV infection

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