protease inhibitor


Definition of protease inhibitor

: a substance that inhibits the action of a protease specifically : any of various drugs (such as indinavir) that inhibit the action of the protease of HIV so that the cleavage of viral proteins into mature functional infectious particles is prevented and that are used especially in combination with other agents in the treatment of HIV infection

Examples of protease inhibitor in a Sentence

Recent Examples on the Web Scientists have now found that protease inhibitors targeted to HIV might have activity against coronavirus, despite the fact that these viruses are unrelated. John Timmer, Ars Technica, "COVID-19: the biology of an effective therapy," 20 Mar. 2020 There is no real evidence that famotidine is effective at treating COVID-19, but the hope is that the drug could prevent the coronavirus from replicating by essentially preoccupying it, similar to how protease inhibitors stop HIV. TheWeek, "Common heartburn medicine being tested on COVID-19 patients in New York," 27 Apr. 2020 That was the stunning benefit of the H.I.V. protease inhibitors that turned the tide of the AIDS epidemic. Jerome Groopman, The New Yorker, "A New Study Questions the Effectiveness of a Potential “Game Changer” Against the Coronavirus," 1 Apr. 2020 Because lopinavir is quickly broken down in the human body by our own proteases, it is given with low levels of ritonavir, another protease inhibitor, that lets lopinavir persist longer. Jon Cohen, Science | AAAS, "WHO launches global megatrial of the four most promising coronavirus treatments," 22 Mar. 2020 In the early 1990s researchers proposed it as an adjunct to early protease inhibitor drugs to help treat HIV/AIDS. Adam Rogers, Wired, "An Old Malaria Drug May Fight Covid-19—and Silicon Valley's Into It," 19 Mar. 2020 The therapy, sold under the brand name Kaletra in the U.S., is normally used to treat HIV patients and belongs to a class of drugs known as protease inhibitors, which block a key enzyme that helps viruses replicate. WSJ, "You Have Coronavirus Questions, We Have Answers," 13 Mar. 2020 So Ho is stacking his shelves with polymerase and protease inhibitors and other drugs that have been developed to fight HIV and other viruses like viral hepatitis, that can interfere with this replication. Alice Park, Time, "A First-of-Its-Kind Library of Potential Coronavirus Drugs, Built at Columbia University, Funded by China's Richest Person," 26 Feb. 2020 But little people like us, protesting in our little corners, coaxed money for research and cocktail therapies and protease inhibitors. Kevin Fisher-paulson, San Francisco Chronicle, "Tim has left us, but the fight continues," 14 May 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'protease inhibitor.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of protease inhibitor

1943, in the meaning defined above

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The first known use of protease inhibitor was in 1943

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Cite this Entry

“Protease inhibitor.” Dictionary, Merriam-Webster, Accessed 16 Jan. 2021.

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protease inhibitor


Medical Definition of protease inhibitor

: a substance that inhibits the action of a protease specifically : any of various drugs (as indinavir or saquinavir) that inhibit the action of HIV protease so that cleavage of viral proteins into mature infectious particles is prevented and that are used especially in combination with other antiretroviral agents in the treatment of HIV infection

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