prostate-specific antigen

pros·​tate-spe·​cif·​ic antigen

Definition of prostate-specific antigen

: a protease secreted by epithelial cells of the prostate gland that is used in the diagnosis of prostate cancer since its concentration in blood serum tends to be proportional to the clinical stage of the disease abbreviation PSA

Examples of prostate-specific antigen in a Sentence

Recent Examples on the Web Cancer is absent in about 70% of patients who show elevated levels of prostate-specific antigen and 7% to 12% those with suspicious mammograms. Allysia Finley, WSJ, 8 Oct. 2021 The ratio is even worse for PSA (prostate-specific antigen) tests for prostate cancer in men. John Horgan, Scientific American, 30 Sep. 2021 Their tumors were more likely to shrink, their prostate-specific antigen levels were more likely to fall, and the risk of their cancer progressing was reduced by 60 percent. New York Times, 24 June 2021 Tyler said his cancer was first detected during a routine physical exam at age 56, when his doctor ordered a prostate-specific antigen (PSA) blood test. Carolyn L. Todd, SELF, 21 June 2021 For instance, knowing that prostate cancer is more common in Black men than in white men, a urologist might have a lower threshold for doing a prostate biopsy based on a borderline elevated prostate-specific antigen (PSA) level in a Black man. Scientific American, 26 Mar. 2021 For prostate cancer, the screening may include a digital rectal exam (DRE) or a blood test that tests for prostate-specific antigen (PSA) levels. Alice Oglethorpe, Country Living, 2 Mar. 2021 Within six months, his prostate-specific antigen, the protein secreted by cancer cells that oncologists use to measure a patient’s cancer, went down to zero, his bone lesions mostly disappeared, and Olson started to feel like his old self again. Sarah Elizabeth Richards, Wired, 19 Nov. 2020 Al's diagnosis came about after a routine physical yielded an elevated prostate-specific antigen (PSA) in his bloodwork. Kayla Keegan, Good Housekeeping, 7 Nov. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'prostate-specific antigen.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of prostate-specific antigen

1979, in the meaning defined above

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The first known use of prostate-specific antigen was in 1979

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Dictionary Entries Near prostate-specific antigen

prostate gland

prostate-specific antigen


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Cite this Entry

“Prostate-specific antigen.” Dictionary, Merriam-Webster, Accessed 26 Jan. 2022.

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More Definitions for prostate-specific antigen

prostate-specific antigen


Medical Definition of prostate-specific antigen

: a protease that is secreted by the epithelial cells of the prostate and is used in the diagnosis of prostate cancer since its concentration in the blood serum tends to be proportional to the clinical stage of the disease abbreviation PSA

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