1
: a system of betting (as on horse races) in which the bettor must pick the winners of six consecutive races
… is one of 42 individuals holding the 78 tickets that legitimately had five out of six winners in the Breeders' Cup pick-six wager.Bill Finley
2
American football : an interception returned by the intercepting team for a touchdown
By halftime he had thrown two interceptions—the second a 69-yard pick-six to outside linebacker and Most Valuable Player Malcolm Smith …S. L. Price

Examples of pick-six in a Sentence

Recent Examples on the Web
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Monday’s practice ended with a Jaxson Dart pick-six to Abdul Carter, after a tip at the line by Kayvon Thibodeaux, and a Jameis Winston interception to safety Ar’Darius Washington. Pat Leonard, New York Daily News, 18 Aug. 2026 Dugger also had a would-be pick-six Wednesday on an Adrian Martinez pass deflected by Jones. Cam Inman, Mercury News, 7 Aug. 2026 Dodson would have scored a pick-six touchdown if offensive lineman Kadyn Proctor hadn’t run downfield and stopped him at the 5-yard line. Omar Kelly august 3, Miami Herald, 3 Aug. 2026 Thibodeaux tallied a pick-six during the first period of practice, stepping in front of a Jameis Winston pass and racing the other way. Dan Duggan, New York Times, 30 July 2026 See All Example Sentences for pick-six

Word History

First Known Use

1980, in the meaning defined at sense 1

Time Traveler
The first known use of pick-six was in 1980

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Cite this Entry

“Pick-six.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/pick-six. Accessed 21 Aug. 2026.

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