: a tumor suppressor gene that in an inactivated form tends to be associated with a high risk of certain cancers

Examples of p53 in a Sentence

Recent Examples on the Web And, at the same time this is happening, a large number of other pathways also feed into the activity of p53. John Timmer, Ars Technica, 29 Mar. 2024 Studies on the closely related SARS-CoV have implicated viral proteins in the possible degradation of p53 and pRB, which are critical oncosuppressors. Carolyn Barber, Fortune, 23 Nov. 2023 Another obvious example would be the p53 gene, which is very strongly associated with cancer suppression. Bill Gifford, Scientific American, 31 July 2023 In mammals, p53 plays a crucial role in preventing mutated cells from turning into tumors. Rachel Nuwer, Scientific American, 8 Sep. 2022 See all Example Sentences for p53 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'p53.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


from p53, the protein made by the gene, from protein + 53, the gene's molecular weight

First Known Use

1990, in the meaning defined above

Time Traveler
The first known use of p53 was in 1990

Dictionary Entries Near p53

Cite this Entry

“P53.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/p53. Accessed 24 Jul. 2024.

Medical Definition

: a tumor suppressor gene that in a defective form tends to be associated with a high risk of certain cancers (as of the colon, lung, and breast)

More from Merriam-Webster on p53

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