nucleotide

noun
nu·​cle·​o·​tide | \ ˈnü-klē-ə-ˌtīd How to pronounce nucleotide (audio) , ˈnyü- \

Definition of nucleotide

: any of several compounds that consist of a ribose or deoxyribose sugar joined to a purine or pyrimidine base and to a phosphate group and that are the basic structural units of nucleic acids (such as RNA and DNA) — compare nucleoside

Examples of nucleotide in a Sentence

Recent Examples on the Web Together with Adam Phillippy, a computational biologist at the National Human Genome Research Institute, Miga launched the Telomere-to-Telomere (T2T) consortium in 2018 to finally sequence every last nucleotide of human DNA. Quanta Magazine, 8 Sep. 2021 Once it is recopied, the replicating polymerase develops transition mutations, where a U nucleotide is converted to a C and a C to U. William A. Haseltine, Forbes, 8 Oct. 2021 The joint effects of five single-nucleotide mutations in beta-lactamase can increase its antibiotic resistance by a factor of 100,000. Quanta Magazine, 11 Jan. 2022 Historically, scientists had to create mutations one nucleotide or amino acid at a time, then purify the mutant protein and assess its function. Quanta Magazine, 11 Jan. 2022 These include an amino acid change observed in the NSP12 polymerase, P323L, and a single nucleotide change occurred in the five prime untranslated region, C241U. William A. Haseltine, Forbes, 14 Oct. 2021 This protein is the engine of the transcription-replication complex, reading nucleotide sequences and copying them for the creation of new RNA. William A. Haseltine, Forbes, 22 Oct. 2021 Of the 64 possible combinations of codons in every three-nucleotide sequence, there are six possible codons that encode arginine. Ethan Siegel, Forbes, 11 June 2021 The mutation closest to the 5’ end of the genome is the C241U nucleotide substitution. William A. Haseltine, Forbes, 3 Sep. 2021 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'nucleotide.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of nucleotide

1908, in the meaning defined above

History and Etymology for nucleotide

International Scientific Vocabulary, irregular from nucle- + -ide

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Time Traveler for nucleotide

Time Traveler

The first known use of nucleotide was in 1908

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Dictionary Entries Near nucleotide

nucleotidase

nucleotide

nucleus

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Statistics for nucleotide

Last Updated

5 May 2022

Cite this Entry

“Nucleotide.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/nucleotide. Accessed 27 Jun. 2022.

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More Definitions for nucleotide

nucleotide

noun
nu·​cle·​o·​tide | \ ˈn(y)ü-klē-ə-ˌtīd How to pronounce nucleotide (audio) \

Medical Definition of nucleotide

: any of several compounds that consist of a ribose or deoxyribose sugar joined to a purine or pyrimidine base and to a phosphate group and that are the basic structural units of RNA and DNA — compare nucleoside

More from Merriam-Webster on nucleotide

Britannica.com: Encyclopedia article about nucleotide

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