misfold

play
verb mis·fold \ˌmis-ˈfōld\

Definition of misfold

of a protein

  1. intransitive verb
  2. :  to fold into an incorrect three-dimensional shape that is typically nonfunctional and often resistant to breakdown Prions force proteins to misfold throughout the nervous system and bone marrow, eventually ravaging the brain and crippling the afflicted cow. — Cathy Booth Thomas

misfolded

play \ˌmis-ˈfōl-dəd\ adjective Scientists have identified a handful of diseases caused by misfolded proteins called prions … — Nathan Seppa

1971

First Known Use of misfold

1971


Medical Dictionary

misfold

play
transitive verb mis·fold \ˌmis-ˈfōld\

Medical Definition of misfold

misfolded

;

misfolding

  1. of a protein :  to fold into an incorrect three-dimensional shape that is typically nonfunctional and often resistant to breakdown The abnormal prions induce normal prion proteins to misfold, and eventually the brain develops spongelike holes.—Bette Hileman, Chemical & Engineering News, 5 Jan. 2004

misfolded

adjective These findings may help researchers develop new treatments for Alzheimer's disease and other kinds of neurodegenerative disorders associated with an accumulation of misfolded proteins in cells.—Alison McCook, Scientific American, April 2001

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