Definition of misfold
of a protein
: to fold into an incorrect three-dimensional shape that is typically nonfunctional and often resistant to breakdown Prions force proteins to misfold throughout the nervous system and bone marrow, eventually ravaging the brain and crippling the afflicted cow. — Cathy Booth Thomas
misfoldedplay \ˌmis-ˈfōl-dəd\ adjective Scientists have identified a handful of diseases caused by misfolded proteins called prions … — Nathan Seppa
Recent Examples of misfold from the Web
In which book was a puffy, misfolded map found on a workbench?
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First Known Use of misfold
Medical Definition of misfold
of a protein : to fold into an incorrect three-dimensional shape that is typically nonfunctional and often resistant to breakdown The abnormal prions induce normal prion proteins to misfold, and eventually the brain develops spongelike holes.—Bette Hileman, Chemical & Engineering News, 5 Jan. 2004
misfoldedadjective These findings may help researchers develop new treatments for Alzheimer's disease and other kinds of neurodegenerative disorders associated with an accumulation of misfolded proteins in cells.—Alison McCook, Scientific American, April 2001
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