mes·​ca·​line | \ ˈme-skə-lən How to pronounce mescaline (audio) , ˈme-skə-ˌlēn \

Definition of mescaline

: a hallucinatory crystalline alkaloid C11H17NO3 that is the chief active principle in peyote buttons

Examples of mescaline in a Sentence

Recent Examples on the Web Entheon’s test looks at the individual’s HTR2A genotype, which can be a predictor for density of 5-HT2A, a serotonin receptor known as the main receptor to interact with classic psychedelic compounds such as LSD, psilocybin, DMT and mescaline. Natan Ponieman, Forbes, "Can A Genetic Test Prevent Risk In Psychedelic Therapy? These Companies Are Betting On It," 27 Apr. 2021 Smoking weed is normal, despite the plant being listed as a Schedule 1 drug by the United States Drug Enforcement Administration, alongside such substances as heroin, bath salts, and mescaline. Nicholas Quah, Vulture, "Facebook Bursts Into the Live Audio Scene," 20 Apr. 2021 The most common types of psychedelic drugs found in Massachusetts are psilocybin, derived from mushrooms, and mescaline, the psychedelic substance found in certain types of cactus plants, usually the peyote cactus., "Should Massachusetts decriminalize psychedelic plants?," 16 Apr. 2021 The bill, introduced Thursday by state Sen. Scott Wiener, a Democrat who represents San Francisco, would decriminalize substances such as psilocybin, MDMA, LSD, ketamine, DMT and mescaline. NBC News, "New California bill would decriminalize psychedelics, expunge criminal records," 18 Feb. 2021 Many people have noted the remarkable resemblance between these images and hallucinations produced by tripping on LSD, mescaline or psilocybin mushrooms. Christof Koch, Scientific American, "Teaching Machines to See," 1 Nov. 2015 To them, adrenochrome became a psychotropic, akin to mescaline. Brian Friedberg, Wired, "The Dark Virality of a Hollywood Blood-Harvesting Conspiracy," 31 July 2020 Shortly thereafter, Osmond was contacted by Aldous Huxley, who was eagerly seeking samples of mescaline. John Semley, The New Republic, "Turn On, Tune In, Cash In," 27 Apr. 2020 In the 1950s, English psychiatrist Humphry Osmond began experiments in Canada with mescaline, a psychedelic naturally occurring in a group of cactus plants. John Semley, The New Republic, "Turn On, Tune In, Cash In," 27 Apr. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'mescaline.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of mescaline

1896, in the meaning defined above

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The first known use of mescaline was in 1896

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Statistics for mescaline

Last Updated

5 May 2021

Cite this Entry

“Mescaline.” Dictionary, Merriam-Webster, Accessed 11 May. 2021.

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More Definitions for mescaline



English Language Learners Definition of mescaline

: a drug that comes from a cactus and that makes people see things that are not real


mes·​ca·​line | \ ˈmes-kə-lən How to pronounce mescaline (audio) , -ˌlēn How to pronounce mescaline (audio) \

Medical Definition of mescaline

: a hallucinatory crystalline alkaloid C11H17NO3 that is the chief active principle in peyote buttons

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