melanoma

noun

mel·​a·​no·​ma ˌme-lə-ˈnō-mə 

plural melanomas also melanomata ˌme-lə-ˈnō-mə-tə 

1

: a tumor containing dark pigment

2

: a highly malignant tumor that starts in melanocytes of normal skin or moles and metastasizes rapidly and widely

Examples of melanoma in a Sentence

Recent Examples on the Web

The vaccine, in combination with Keytruda , met key goals in patients with higher-risk or advanced melanoma whose detectable cancer had been completely removed through surgery. — Deena Zaidi, CNBC, 22 Aug. 2026

When used alone after surgery to reduce the risk that melanoma returns, Keytruda is given every three to six weeks for up to a year. — CNN Money, 21 Aug. 2026

The phase 3 trial involved 1,137 high-risk patients with melanoma, who were randomly assigned to receive either the vaccine and the immunotherapy drug Keytruda, or just Keytruda, for about a year. — Harriet Marsden, TheWeek, 21 Aug. 2026

Now, the $56 billion company has been credited with developing one of the first successful mRNA (COVID-19) vaccines, and is making headway with its melanoma trials. — Emma Burleigh, Fortune, 20 Aug. 2026

Word History

Etymology

melan- (in melanosis, melanotic) + -oma

First Known Use

1838, in the meaning defined at sense 1

Phrases Containing melanoma

• malignant melanoma

Rhymes for melanoma

• ambystoma
• atheroma
• carcinoma
• coloboma
• granuloma
• haematoma
• hamartoma
• hemangioma
• hematoma
• hepatoma
• hybridoma
• myeloma

Kids Definition

melanoma

noun

mel·​a·​no·​ma ˌmel-ə-ˈnō-mə 

plural melanomas also melanomata -mət-ə 

: a usually malignant tumor containing dark pigment

Medical Definition

melanoma

noun

mel·​a·​no·​ma ˌmel-ə-ˈnō-mə 

plural melanomas also melanomata -mət-ə 

1

: a benign or malignant skin tumor containing dark pigment

2

: a tumor of high malignancy that starts in melanocytes of normal skin or moles and metastasizes rapidly and widely

called also malignant melanoma, melanocarcinoma, melanoepithelioma, melanosarcoma