li·​do·​caine ˈlī-də-ˌkān How to pronounce lidocaine (audio)
: a crystalline compound C14H22N2O that is used in the form of its hydrochloride as a local anesthetic and as an antiarrhythmic agent

Examples of lidocaine in a Sentence

Recent Examples on the Web As the first step of the treatment, your dermatologist will usually apply topical lidocaine for 15 to 30 minutes prior. India Espy-Jones, Essence, 3 Apr. 2024 To ease the discomfort of the rash, the Centers for Disease Control and Prevention recommend taking an oral antihistamine (such as Benadryl) or applying topical treatments such as benzocaine, lidocaine, or calamine lotion. Stephen C. George, Discover Magazine, 5 Mar. 2024 There are a variety of genital and oral herpes treatments that can help prevent outbreaks, alleviate symptoms, and lower the risk of transmission, including antiviral medication like valacyclovir and acyclovir, acyclovir cream for cold sores, lidocaine pain cream, Cover Up! Danielle Sinay, Glamour, 5 Mar. 2024 The list includes products that contain lidocaine and morphine but not the coronavirus vaccine, which isn’t produced in Rocky Mount. Andrew Jeong, Washington Post, 25 July 2023 These include essentials like lidocaine injections, local anesthetic needed for surgery and even for simpler procedures like stitches. Jen Christensen, CNN, 6 Feb. 2024 Instead, the results revealed Muñoz died from a fatal combination of morphine, Demerol, Versed, propofol, ketamine, lidocaine and Narcan – almost all drugs typically used in surgery and ones to which her nurse anesthetist husband would have access, per the special. Christina Coulter, Fox News, 23 Dec. 2023 So, positive for morphine, Demerol, Versed, propofol -- ketamine, lidocaine, Narcan. Erin Moriarty, CBS News, 16 Dec. 2023 Luis Mata that Joel Pellot had often brought drugs to her home – some for his own recreational use — including ketamine, morphine, lidocaine, fentanyl and more. Erin Moriarty, CBS News, 16 Dec. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'lidocaine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


acetanilid + -o- + -caine

First Known Use

circa 1949, in the meaning defined above

Time Traveler
The first known use of lidocaine was circa 1949

Dictionary Entries Near lidocaine

Cite this Entry

“Lidocaine.” Dictionary, Merriam-Webster, Accessed 22 May. 2024.

Medical Definition


li·​do·​caine ˈlīd-ə-ˌkān How to pronounce lidocaine (audio)
: a crystalline compound C14H22N2O used as a local anesthetic often in the form of its hydrochloride C14H22N2O·HCl

called also lignocaine

see xylocaine

More from Merriam-Webster on lidocaine

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!