leu·​ko·​tri·​ene ˌlü-kō-ˈtrī-ˌēn How to pronounce leukotriene (audio)
: any of a group of eicosanoids that participate in allergic responses (such as bronchial constriction)

Examples of leukotriene in a Sentence

Recent Examples on the Web Other protiens found in their saliva, such as tryptase and leukotrienes, can directly cause itchiness. Emily Shiffer, Health, 7 Mar. 2023 The risk was lower in people who took a drug that blocked leukotrienes. Stacey Burling, Philly.com, 8 June 2018 The Temple researchers tried the drug because of their previous work on leukotrienes, inflammatory molecules that don’t work properly in Alzheimer’s disease or frontotemporal dementia. Stacey Burling, Philly.com, 8 June 2018 Leukotrienes are similar to histamine, but 100 to 1,000 times more potent in the lung than a similar weight of histamine. Bradley J. Fikes, sandiegouniontribune.com, 21 June 2017 The scientists found that the drug prevented tissue injury and fluid buildup by blocking a protein called leukotriene B4 (LTB4). Amy Norton, chicagotribune.com, 11 May 2017

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'leukotriene.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1979, in the meaning defined above

Time Traveler
The first known use of leukotriene was in 1979

Dictionary Entries Near leukotriene

Cite this Entry

“Leukotriene.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/leukotriene. Accessed 4 Dec. 2023.

Medical Definition


leu·​ko·​tri·​ene ˌlü-kə-ˈtrī-ˌēn How to pronounce leukotriene (audio)
: any of a group of eicosanoids that are generated in basophils, mast cells, macrophages, and human lung tissue by lipoxygenase-catalyzed oxygenation especially of arachidonic acid and that participate in allergic responses (as bronchoconstriction in asthma) see slow-reacting substance of anaphylaxis

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