leu·​ko·​tri·​ene | \ ˌlü-kō-ˈtrī-ˌēn How to pronounce leukotriene (audio) \

Definition of leukotriene

: any of a group of eicosanoids that participate in allergic responses (such as bronchial constriction)

Examples of leukotriene in a Sentence

Recent Examples on the Web The risk was lower in people who took a drug that blocked leukotrienes. Stacey Burling, Philly.com, 8 June 2018 The Temple researchers tried the drug because of their previous work on leukotrienes, inflammatory molecules that don’t work properly in Alzheimer’s disease or frontotemporal dementia. Stacey Burling, Philly.com, 8 June 2018 Leukotrienes are similar to histamine, but 100 to 1,000 times more potent in the lung than a similar weight of histamine. Bradley J. Fikes, sandiegouniontribune.com, 21 June 2017 The scientists found that the drug prevented tissue injury and fluid buildup by blocking a protein called leukotriene B4 (LTB4). Amy Norton, chicagotribune.com, 11 May 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'leukotriene.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of leukotriene

1979, in the meaning defined above

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The first known use of leukotriene was in 1979

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Cite this Entry

“Leukotriene.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/leukotriene. Accessed 13 Aug. 2022.

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More Definitions for leukotriene


leu·​ko·​tri·​ene | \ ˌlü-kə-ˈtrī-ˌēn How to pronounce leukotriene (audio) \

Medical Definition of leukotriene

: any of a group of eicosanoids that are generated in basophils, mast cells, macrophages, and human lung tissue by lipoxygenase-catalyzed oxygenation especially of arachidonic acid and that participate in allergic responses (as bronchoconstriction in asthma) — see slow-reacting substance of anaphylaxis

More from Merriam-Webster on leukotriene

Britannica.com: Encyclopedia article about leukotriene


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