leptin

noun

lep·​tin ˈlep-tən How to pronounce leptin (audio)
: a peptide hormone that is produced by fat cells and plays a role in body weight regulation by acting on the hypothalamus to suppress appetite and burn fat stored in adipose tissue

Examples of leptin in a Sentence

Recent Examples on the Web
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In late September 2020, a Mass General endocrinologist called with the test results: Ben had a leptin deficiency. Wendy Grossman Kantor, People.com, 7 Aug. 2025 Sleep deprivation is also associated with disruptions in appetite-regulating hormones (ghrelin and leptin), which often increases cravings for sugary, nutrient-poor foods.12 2. Lauren Panoff, Verywell Health, 25 July 2025 Their nutrient profile also helps regulate appetite hormones like ghrelin and leptin, which control hunger and satiety. 4. Bryan Robinson, Forbes.com, 7 Apr. 2025 Exercise can help balance leptin and ghrelin, hormones involved in hunger, energy balance, and sleep. Wendy Wisner, Health, 31 Mar. 2025 See All Example Sentences for leptin

Word History

Etymology

Greek leptos slender + English -in entry 1

First Known Use

1995, in the meaning defined above

Time Traveler
The first known use of leptin was in 1995

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Cite this Entry

“Leptin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/leptin. Accessed 10 Sep. 2025.

Medical Definition

leptin

noun
lep·​tin ˈlep-tən How to pronounce leptin (audio)
: a peptide hormone that is produced by fat cells and plays a role in body weight regulation by acting on the hypothalamus to suppress appetite and burn fat stored in adipose tissue

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