in·​vag·​i·​nate | \ in-ˈva-jə-ˌnāt How to pronounce invaginate (audio) \
invaginated; invaginating

Definition of invaginate

transitive verb

2 : to fold in so that an outer becomes an inner surface

First Known Use of invaginate

circa 1656, in the meaning defined at transitive sense 1

History and Etymology for invaginate

Medieval Latin invaginatus, past participle of invaginare, from Latin in- + vagina sheath

Keep scrolling for more

Learn More about invaginate

Time Traveler for invaginate

Time Traveler

The first known use of invaginate was circa 1656

See more words from the same year

Statistics for invaginate

Cite this Entry

“Invaginate.” Dictionary, Merriam-Webster, Accessed 10 Jul. 2020.

Keep scrolling for more

More Definitions for invaginate


in·​vag·​i·​nate | \ in-ˈvaj-ə-ˌnāt How to pronounce invaginate (audio) \
invaginated; invaginating

Medical Definition of invaginate

transitive verb

1 : to cover or enclose (as within the body)
2 : to fold in so that an outer becomes an inner surface invaginate the sac into the lumen— E. A. Graham

intransitive verb

: to undergo invagination a condition in which a portion of the intestine invaginates into the adjacent segmentNew England Journal of Medicine

Comments on invaginate

What made you want to look up invaginate? Please tell us where you read or heard it (including the quote, if possible).


See Definitions and Examples »

Get Word of the Day daily email!

Test Your Vocabulary

Words for Summer: A Quiz

  • a closeup of a sunflower
  • Which of the following words means “of or relating to summer”?
Spell It

Can you spell these 10 commonly misspelled words?

Dictionary Devil

Test Your Knowledge - and learn some interesting things along the way.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!