insulin resistance

noun

Definition of insulin resistance

: reduced sensitivity to insulin by the body's insulin-dependent processes (such as glucose uptake and lipolysis) that is typical of type 2 diabetes but often occurs in the absence of diabetes

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With advanced age comes the potential for a loss in strength — dynapenia — and muscle mass — sarcopenia — with extreme cases yielding a significant increase in fat mass — known as sarcopenic obesity — the result of insulin resistance. — Mackie Shilstone, nola.com, "Vitamin D reduces risk to fat gain in old age," 19 June 2019 Another prevalent theory holds that insulin resistance is at the root of PCOS. — Mary Claire Lagroue, SELF, "Can Diet and Exercise Actually Improve PCOS Symptoms?," 23 Apr. 2019 Over the long term, these conditions help our bodies to stave off soaring blood sugar, insulin resistance and type 2 diabetes. — Gretchen Reynolds, The Seattle Times, "Planning a break from exercise? Think twice," 8 Aug. 2018 In type 2 diabetes, the form of the disease that’s more common in adults, people usually have insulin resistance, meaning the insulin is less effective, the Mayo Clinic explains. — Carolyn L. Todd, SELF, "Why a ‘Sugar Hangover’ Can Feel as Terrible as the Real Thing," 27 Oct. 2018 The bigger breakfast group also experienced greater reductions in fasting glucose, insulin and insulin resistance scores, all of which indicate decreased risk for type 2 diabetes, according to the study's authors. — Lisa Drayer, CNN, "Weight loss can be tied to when, not just what, you eat," 8 Mar. 2018 For some people, insulin resistance eventually leads to prediabetes and type 2 diabetes as the pancreas can’t make enough insulin to keep blood glucose in the normal range, meaning extra glucose stays in your bloodstream. — Sarah Jacoby, SELF, "The Science on Weight and Health," 26 June 2018 Inflammation is not present in Type 2, but abnormal metabolic markers are, including insulin resistance and extremely low levels of certain vitamins and hormones. — Linda Marsa, Discover Magazine, "A New Treatment for Alzheimer's? It Starts With Lifestyle," 16 Nov. 2018 Typically, each plan encompasses several key elements to reverse inflammation, insulin resistance and destruction of vital brain structures. — Linda Marsa, Discover Magazine, "A New Treatment for Alzheimer's? It Starts With Lifestyle," 16 Nov. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'insulin resistance.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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insulin-like growth factor

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insulin resistance syndrome

insulin shock

Insull

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Last Updated

5 Jul 2019

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The first known use of insulin resistance was in 1927

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insulin resistance

noun

Medical Definition of insulin resistance

: reduced sensitivity to insulin by the body's insulin-dependent processes (as glucose uptake, lipolysis, and inhibition of glucose production by the liver) that results in decreased activity of these processes or an increase in insulin production or both and that is typical of type 2 diabetes but often occurs in the absence of diabetes