insulin resistance


Definition of insulin resistance 

: reduced sensitivity to insulin by the body's insulin-dependent processes (such as glucose uptake and lipolysis) that is typical of type 2 diabetes but often occurs in the absence of diabetes

Examples of insulin resistance in a Sentence

Recent Examples on the Web

Both the control group and 16:8 diet group had similar figures for fat mass, cholesterol and insulin resistance. Fiza Pirani, ajc, "Does daily fasting help with weight loss? About the 16:8 diet," 19 June 2018 But the exact way an excess amount of fat contributes to insulin resistance isn’t totally understood. Sarah Jacoby, SELF, "The Science on Weight and Health," 26 June 2018 After four days of sitting nonstop, the men and women showed greater insulin resistance and undesirable changes in their cholesterol levels. Gretchen Reynolds, New York Times, "Exercise vs. Standing? You Probably Need to Do Both," 13 June 2018 Yo-yo dieting leads to weight cycling, which may contribute to chronic inflammation, insulin resistance, and cardiovascular disease. Wendy Lopez, SELF, "I'm a Registered Dietitian and These Are the Only 3 Healthy Eating 'Rules' I Live By," 7 May 2018 According to the report, mechanisms that contribute to the high risk of heart disease include dietary choices, lack of physical activity, greater insulin resistance, blood fat levels, obesity, and hypertension, among other factors. Monica Luhar /, NBC News, "New report details high heart disease risk in South Asians in U.S.," 29 June 2018 There are numerous theories about why some women don’t develop enough milk-making material during adolescence: Some studies point to exposure to toxins, other research has been zeroing in on insulin resistance as a cause. Reyhan Harmanci, The Cut, "What No One Tells You About Not Being Able to Breastfeed," 23 May 2018 High trans fat intakes may be associated with an increase in fat in the abdominal cavity, insulin resistance and type 2 diabetes. Shauna Downs,, "FDA's new ban on trans fats could prevent 20,000 heart attacks annually," 13 June 2018 This hazard most likely results from the harmful effects of this protein on insulin resistance, the precursor to Type 2 diabetes, and development of the metabolic syndrome, a complex of cardiac risk factors. New York Times, "The Dangers of Belly Fat," 11 June 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'insulin resistance.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of insulin resistance

1927, in the meaning defined above

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Last Updated

11 Oct 2018

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The first known use of insulin resistance was in 1927

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insulin resistance


Medical Definition of insulin resistance 

: reduced sensitivity to insulin by the body's insulin-dependent processes (as glucose uptake, lipolysis, and inhibition of glucose production by the liver) that results in decreased activity of these processes or an increase in insulin production or both and that is typical of type 2 diabetes but often occurs in the absence of diabetes

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