hy·​droxy·​zine hī-ˈdräk-sə-ˌzēn How to pronounce hydroxyzine (audio)
: a compound C21H27ClN2O2 used as an antihistamine and tranquilizer

Examples of hydroxyzine in a Sentence

Recent Examples on the Web With the help of hydroxyzine, these symptoms can be greatly reduced, improving our dog's quality of life. Amber Smith, Discover Magazine, 22 June 2023 Lyrica, oxycodone, nadolol, hydroxyzine, Cymbalta, gabapentin. William Wan, Washington Post, 12 June 2023 The Mercer County Prosecutor's Office revealed Wednesday that the 20-year-old junior took her own life by ingesting a fatal dose of bupropion, escitalopram and hydroxyzine. Rebecca Rosenberg, Fox News, 29 Dec. 2022 Bupropion and escitalopram – known by the brand names Wellbutrin and Lexapro – are primarily prescribed for depression, while hydroxyzine is an antihistamine that treats allergies and anxiety. Rebecca Rosenberg, Fox News, 29 Dec. 2022 Smith-Fields’ autopsy results indicated that her cause of death was a combination of fentanyl, promethazine, hydroxyzine, and alcohol. Jenna Caldwell, Time, 17 Feb. 2022 In her purse, police found several medications, including tramadol, suspected Ambien, vitamin E, butalbital-acetaminophen-caffeine, ferrous sulfate, hydroxyzine hydrochloride and nadolol. Bob Sandrick, cleveland, 27 Dec. 2019 Tests by the Office of the Chief Medical Examiner showed Dustin died of acute intoxication from the combined effects of fentanyl, hydroxyzine and a compound used to make fentanyl called 4-ANPP. Jesse Leavenworth, courant.com, 19 Nov. 2019 An autopsy revealed the victim died from an overdose of hydroxyzine, fentanyl and morphine, the affidavit said. Nicholas Rondinone, courant.com, 24 May 2017 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'hydroxyzine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


hydroxy- + piperazine

First Known Use

1956, in the meaning defined above

Time Traveler
The first known use of hydroxyzine was in 1956

Dictionary Entries Near hydroxyzine

Cite this Entry

“Hydroxyzine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hydroxyzine. Accessed 3 Oct. 2023.

Medical Definition


hy·​droxy·​zine hī-ˈdräk-sə-ˌzēn How to pronounce hydroxyzine (audio)
: a compound that is administered usually in the form of its dihydrochloride C21H27ClN2O2·2HCl or pamoate C21H27ClN2O2·C23H16O6 and is used as an antihistamine and tranquilizer see vistaril
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