gene conversion


Definition of gene conversion

: a genetic process that involves nonreciprocal meiotic recombination in heterozygotes in which a mismatched DNA sequence from one heteroduplex DNA strand is replaced with a sequence complementary to the other strand resulting in aberrant gametic ratios (such as 3:1) and that is observed especially in ascomycetous fungi

Examples of gene conversion in a Sentence

Recent Examples on the Web Their new experiments suggest that embryos borrow DNA templates from themselves to make repairs—a process called gene conversion—up to 40 percent of the time. Megan Molteni, Wired, "In Embryos, Crispr Can Cut Out Whole Chromosomes—That's Bad," 29 Oct. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'gene conversion.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of gene conversion

1955, in the meaning defined above

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The first known use of gene conversion was in 1955

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Cite this Entry

“Gene conversion.” Dictionary, Merriam-Webster, Accessed 18 Jan. 2021.

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gene conversion


Medical Definition of gene conversion

: a genetic process that is sometimes associated with meiotic recombination in heterozygotes if heteroduplex DNA is formed, that involves the selective enzymatic excision of a mismatched DNA sequence from one heteroduplex strand and replacement with a nucleotide sequence complementary to the other strand so that the two DNA strands are genetically identical, and that results in aberrant gametic ratios (as 3:1 or 1:3 instead of 2:2)

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