fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil How to pronounce fentanyl (audio)
nonstandard -ˌnȯl
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Early this month, a grand jury indicted Michael Antonio Cruz on charges of conspiracy to possess with intent to distribute methamphetamine and fentanyl as well as possession with intent to distribute fentanyl. — Dan Raby, CBS News, 12 Nov. 2026 The medical examiner’s report said toxicological screenings showed that Chase had methamphetamine and fentanyl in her system. — Ingrid Vasquez, PEOPLE, 11 Nov. 2026 The artist Lucien Smith died from an accidental overdose of fentanyl and oxycodone, stated the New York City medical examiner’s office. — Devorah Lauter, ARTnews.com, 6 Nov. 2026 On April 24, investigators allegedly purchased 2 kilograms of fentanyl from Davy, according to court records. — Staff Report, Hartford Courant, 5 Nov. 2026 See All Example Sentences for fentanyl

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of fentanyl was in 1964

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Cite this Entry

“Fentanyl.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fentanyl. Accessed 14 Nov. 2026.

Medical Definition

: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.

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