fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil How to pronounce fentanyl (audio)
nonstandard -ˌnȯl
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Two days later, investigators searched his hotel room and reported finding nearly 700 grams of cocaine, more than 70 grams of fentanyl, drug packaging materials and $13,867, according to authorities. — Justin Muszynski, Hartford Courant, 2 Oct. 2026 According to North Carolina data, Rowan County has the second-highest fentanyl-positive death rate in the state. — Julia Coin october 1, Charlotte Observer, 1 Oct. 2026 Like morphine and fentanyl, cychlorphine locks onto the brain’s mu-opioid receptors, reducing pain and increasing euphoria. — New Atlas, 30 Sep. 2026 Milania Giudice allegedly had fentanyl in her system, Teresa Giudice claimed in bodycam video. — Tracy Wright, FOXNews.com, 29 Sep. 2026 See All Example Sentences for fentanyl

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of fentanyl was in 1964

Browse Nearby Words

Cite this Entry

“Fentanyl.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fentanyl. Accessed 5 Oct. 2026.

Medical Definition

: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.

More from Merriam-Webster on fentanyl

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!