fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil 

: a synthetic opioid narcotic analgesic C₂₂H₂₈N₂O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C₂₂H₂₈N₂O·C₆H₈O₇ is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web

Some 80,400 Americans died of drug overdoses in 2024, nearly 70% more than a decade earlier; synthetic opioids, mainly fentanyl, accounted for nearly 68% of those deaths. —The Week Us, TheWeek, 18 May 2026

Naloxone, the ingredient in Narcan, is an antidote for opioid overdoses, but because xylazine is not an opioid, the emergency medicine only stops the effects of fentanyl, not the tranquilizer, making those who overdose more likely to have lethal repercussions. —Anna Giaritelli, The Washington Examiner, 17 May 2026

The leader of a Connecticut drug trafficking organization was sentenced to more than 15 years in federal prison for distributing large quantities of fentanyl, heroin and cocaine in and around Norwalk. —Staff Report, Hartford Courant, 16 May 2026

Fueled by fentanyl and a new, psychosis-inducing form of methamphetamine, street homelessness is no longer confined to the 50 hellish blocks of Skid Row in downtown Los Angeles. —Meghan Daum, The Atlantic, 15 May 2026

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Rhymes for fentanyl

• bunnell
• funnel
• tunnel
• multifunctional

Medical Definition

fentanyl

noun

fen·​ta·​nyl ˈfent-ᵊn-ˌil 

: a synthetic opioid narcotic analgesic C₂₂H₂₈N₂O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C₂₂H₂₈N₂O·C₆H₈O₇ is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.