1548, in the meaning defined at sense 1
Latin enucleatus, past participle of enucleare, literally, to remove the kernel from, from e- + nucleus kernel — more at nucleus
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“Enucleate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/enucleate. Accessed 3 Mar. 2021.
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