en·​gram | \ ˈen-ˌgram How to pronounce engram (audio) \
variants: or less commonly engramme

Definition of engram

: a hypothetical change in neural tissue postulated in order to account for persistence of memory : memory trace

Examples of engram in a Sentence

Recent Examples on the Web That’s an engram every 3-6 games or so, depending on your rank. Paul Tassi, Forbes, 12 Sep. 2021 Over the last decade or so, several groups conducting engram research have begun to suspect that structural changes in the chromatin prime the cell to make and preserve memories. Quanta Magazine, 2 Nov. 2020 Right after the memory formed, there weren’t huge differences in how the engram cells expressed their genes. Quanta Magazine, 2 Nov. 2020 This approach, in an impressive achievement, is now allowing researchers to observe and manipulate specific neurons that encode a specific memory known as an engram, as noted in a 2020 paper in Science. Kenneth S. Kosik, Scientific American, 20 Apr. 2020 The road to that discovery started back in 2012, when Tonegawa’s lab came up with a way to highlight brain cells known as engram cells, which hold a unique memory. Quanta Magazine, 14 Dec. 2017 Josselyn helped lead this wave of research with some of the earliest studies to capture engram neurons in mice. Helen Shen, Scientific American, 14 Mar. 2018 But these types of memory-suppression study sketch out only half of the engram. Helen Shen, Scientific American, 14 Mar. 2018 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'engram.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of engram

1908, in the meaning defined above

History and Etymology for engram

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Cite this Entry

“Engram.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/engram. Accessed 9 Aug. 2022.

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More Definitions for engram


variants: also engramme \ ˈen-​ˌgram How to pronounce engram (audio) \

Medical Definition of engram

: a hypothetical change in neural tissue postulated in order to account for persistence of memory : memory trace

Other Words from engram

engrammic \ en-​ˈgram-​ik How to pronounce engram (audio) \ adjective


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